Talking Hormones, Longevity, and the Science of Thriving

From podcasts and panels to press features and bylines, I’m on a mission to make hormones, longevity, and sexual health part of our everyday conversations.

The Conversations I Keep Coming Back To

Women’s longevity
Menopause & perimenopause (including the Perimenopause Glass Ceiling)
Hormone optimization therapy in women
“SEXponential” health, the surprising relationship between sexual wellness and healthspan
Regenerative medicine (stem cells, exosomes) & advanced clinical therapies

Featured Podcasts

Also Seen On:

The Human Upgrade: Biohacking for Longevity & Performance with Dave Asprey
Boundless Life with Ben Greenfield
Digital Social Hour with Sean Kelly
The Dr. Hyman Show
The Mindvalley Podcast with Vishen Lakhiani
The mindbodygreen Podcast
Be Well by Kelly Leveque

The Broken Brain
Siim Land Podcast
Meisha Tate
The NORMAKAMALIFE podcast
The Resetter Podcast with Dr. Mindy Pelz
Metabolic Freedom With Ben Azadi
Built for Growth by Miesha Tate

Featured Articles

Also Featured In...

Get in Touch

View Instagram post by dr.amybkillen

Mar 28

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I'm so grateful to be on the first ever @lancomeofficial Longevity MD Advisory Board. 💥

Today Lancome reveals its new longevity skincare line, which incorporates Urolithin A (@miropure_official ) from @timeline_longevity .

The idea is to bring the ideals of longevity medicine to skin health.

You'll hear more about this soon! 💃

P.S. Thanks to @drdavidluu for introducing me to this opportunity.

Thanks to @drgabriellelyon and @tiffanymoonmd for joining me in this adventure!

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Mar 27

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1 in 6 perimenopausal women experience suicidal ideation — and most
doctors are missing it completely. 😟

Standard depression screening wasn't designed for hormone-driven mood changes. A new study from Liverpool John Moores University found that HRT reduced suicidal ideation by over
90%!

If you're in perimenopause and struggling, ask your doctor about your hormones — not just an antidepressant.

Have you had depression or mood changes in perimenopause? What did your doctor offer you? ❓

Study: Improving detection and treatment of psychological distress during menopause: evidence from a clinical hormone replacement therapy cohort | BJPsych International | Cambridge Core. Jan 2026.

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Mar 26

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Checking estradiol and progesterone in perimenopause should not prevent you from getting hormone therapy. ❎

You should still get other labs, such as metabolic markers, lipids and inflammatory markers at least yearly (ideally more).

I generally prefer serum (blood) testing for hormones but it's not wrong to also use other tests in the decision-making process.

The standard of care in medicine is classically 14 years behind the cutting edge curve. We need to be open to reviewing new science instead of waiting for someone else to do it for us.

My two cents. 💰

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Mar 25

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I still have the side shave. It reminds me of my daughter, who is fearless.

It reminds me that now is the time. ⏳

To take risks.
To be bold.
To not care if it makes sense to other people.

You'll never be as young as you are today.💪

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Mar 23

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🫠Mind the gap orgasm gap.

95% of men finish,
While only 65% of women do.
Yet somehow we decided women were the problem??

From the G-spot myth to “you should orgasm from penetration,”
This is the sex ed we should’ve gotten.

👉 Comment "SUBSTACK" to get this sent right to you before you blame your body for bad information.

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Mar 21

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Women's strategically placed glute/hip/thigh fat is more metabolically beneficial than centrally-placed belly fat. 💥

Before menopause, this gives us a serious advantages. 🙏

Estrogen and progesterone loss at menopause shifts that "good" fat into the "bad" zones, where it becomes more inflammatory. 😩

I recommend DEXA scans + metabolic blood testing (fasting glucose, fasting insulin, Hbg A1c, hsCRP, lipids) to all midlife women.

Know your baseline so you know when things are changing. ✅

Have you had metabolic testing in the last year? ❓

P.S. While curves certainly have benefits, too much fat is problematic, no matter where it's sitting on the body.

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Mar 20

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Your age at menopause influences cardiovascular disease risk. 😲

Women who go through menopause earlier (if untreated) have a higher risk of heart disease.

Why?

Estrogen protects the CV system through multiple mechanisms, including effects on...
🔺 Lipids
🔺 Inflammation
🔺 Blood sugar
🔺 Blood vessel elasticity
🔺 Vasodilation

Did you go into menopause early? Has your doctor discussed the need to be proactive in CV disease screening with you? ❓

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Mar 19

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Are you at risk? ❓

Early menopause is associated with a 40% increased risk of cardiovascular disease.

Black women are three times more likely to go into early menopause. 🥺

Loss of key hormones, especially estrogen, are a key contributor to the increased risk.

It turns out that the ovaries do a lot more than just make babies. Who knew 🤔😏

Freaney PM et al. Premature Menopause and Lifetime Risk of Coronary Heart Disease. JAMA Cardiol. Published online March 18, 2026. doi:10.1001/jamacardio.2026.0212

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Mar 16

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I love you, but I gotta say it...

Biest is Bull$shit. 🤑

1) Even at concentrations of 1:20 (estradiol: estriol) the estriol doesn't bind the estrogen receptor in any meaningful way.
2) Even if estriol WERE binding the receptor, it would have agonist effects, not antagonist effects, like you're taught (because of the consistent serum steady state of estriol).
3) Estriol as a stand-alone is a crap systemic hormone. It requires very high doses (4-8 mg orally) to improve VSM at at least 2 mg to improve bone density.

Estriol doesn't help with insulin sensitivity, visceral fat, CV prevention, or brain health. ❎

For a full list of sources, see the free section of my Substack article. Comment SUBSTACK below for a link.

P.S. Biest isn't harmful. But it commonly underdoses estradiol, which is the hormone we care about.

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Mar 15

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Your patients are asking about hormones. Are you ready to answer? 🤔

I built the HOT Provider Course because I got tired of watching brilliant clinicians feel lost when their patients asked about hormone therapy. 23 video lessons. 300-page guidebook. 💥

Everything I wish someone had handed me when I started.

But first — grab the free HOT Quick-Start Guide. It's a one-page clinical cheat sheet covering:

✅ The SMARDT prescribing framework
✅ Baseline labs checklist
✅ Key contraindications for male and female hormone therapy
✅ Next steps

Comment "QUICK START" and I'll send you a link to my website. Scroll to add your email and I'll send you the HOT Quick Start Checklist.

Or visit dramykillen.com/hot-provider-course 💪

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Mar 14

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Estrogen has so many positive effects on the immune system! 🥰

During C0vid -19 menopausal women taking estrogen had a 72% lower risk of death compared to women not on hormones.

Wow! 💥

Have you heard about estrogen's immune effects before?? ❓

Source:
Sakulpaisal et al. 2023, Human Reproduction.

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Mar 13

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🫧Bubbly & delicious with 10g protein?
No way!
😎 (Yes Waay!)

Find @drinkwaay in the shelf-stable beverage section by the energy and protein drinks at Whole Foods, Sprouts or on Amazon!
Use code 'KILLENIT' for a discount on Amazon!

With 0g sugar, collagen peptides, no caffeine,
This is a daily ritual you can actually feel good about!

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Mar 11

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Sexponential Health has made it to the big screen! 💥

In 2016 I created the term "Sexponential" after attending an Exponential Medicine conference by futurist @peterdiamandis .

Today, it all came full circle when I stood on Peter's big stage at @abundancesummit and spoke to 800 of his closest friends about the link between sexual health and longevity.

Thanks to all who attended, clapped, laughed, and (at the end) stood, making it clear that in this AI heavy world , the next frontier isn't just exponential growth and MORE MORE MORE, but also Sexponential health and ... Damn, it sure feels good to be human. 🥰

Thanks to @renee.intuitiveliving for the 📷
Thanks to @humanauthealth for the slide deck and support.

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Mar 9

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Does estrogen help your face? 🙄

Topical estradiol and estriol have been shown to improve collagen production in several studies, including a small randomized controlled trial.

But, in one study, topical estrone made aging skin WORSE. 😵

Systemic estrogen may help slow bone resorption, which would be a BIG benefit. But, dose matters!

This week's Substack breaks it all down for you (and includes tons of sources).

Comment "SUBSTACK" for all the deets! 👇

Have you seen skin benefits from estrogen therapy? ❓

P.S. the only study on topical estrone was Yoon 2014, Acta Derm Venereol and did NOT show benefit after 24 weeks. It actually showed an increase in MMP, which breaks down collagen.

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Mar 8

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Transmenopause is a critical intervention window.

This is when we should be starting hormones. 💥

Not 5 years into menopause. Not after much of the damage has been done.

Yes, late start hormones can still have benefits but the most benefits will come when we learn to start prescribing during the critical window.

Save this video and share with your medical provider. ✅

SWAN data are available as multiple published studies - transmenopause was first described by Sowers et al, J Clin Endo Metabolic, 2010.

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Mar 6

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Labia's are back! 💋

I love a chance to talk about the very normal variations in women's "down under" tissues.

Thanks to @houseofmaher and @ilonamaher for this fantastic conversation. 😍

What do you think about the Puffy Labia trend? ❓

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Mar 4

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This is not what I thought I'd be talking about today!

Old to young mouse fecal microbiome transfers resulted in IMPROVED ovarian inflammatory markers and increased ability to get pregnant. 💩

This study is fascinating and reminds us of just how smart and interconnected every system of our body is.

Now, who wants an Old Feces Transfer? Im making a list! 🤣

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Mar 2

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Ah... estrogen and the immune system! 💥

Estrogen acts like a security director, telling immune cells when to attack and, just as importantly, when to stand down.

It also keeps your barriers healthy so pathogens and toxins stay outside your body (think: gut, lungs, vagina). 🫁

In some cases, an estrogen -activated immune response may be TOO STRONG (ex autoimmune disease)

But, in general, estrogen + immune system = love affair (#heatedrivalry ).

Have you noticed immune or inflammatory changes recently? ❓

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Feb 27

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Are you taking a GLP1 agonist? 🤔

Weight loss in menopause can be beneficial, but it can also affect estrogen signalling in women.

Too much, too fast may actually lead to MORE hot flashes, night sweats, joint pain, dry skin, etc because you've lost a key source of estrogen. 😩

This is in women NOT taking hormones.

This is one reason I love GLP1's + Hormone Optimization Therapy (HOT) for midlife women needing weight loss.

And, don't forget to keep training those muscles so you don't lose them along the way. 💪💪

Have you tried the GLP1 + HOT combo? ❓

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Feb 26

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Progesterone isn’t a vibe.
⏰It’s a schedule.

If you still have a uterus,
progesterone = protection… but only if you take it correctly.

Not every other day.
Not “when you remember.”
Not menopause roulette.
🚨 Sporadic progesterone = unprotected uterine lining = real long-term risk.

Check out my (old) Substack article on this "The 411 on Progesterone: Forms, Routes and Dosing Strategies" from Feb, 2025. ✅

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